- In 2006, he enjoyed a successful single, Tell Me When To Go, produced by Lil Jon, which was an unexpected hit.
- Despite being a primarily underground artist, E-40 is considered a "rapper's rapper."
- He opened a Fatburger Franchise in Pleasant Hill, along with former NFL player, Chester McGlockton.
- E-40 has performed at The Gathering of Juggalos.
- Numerous influential rappers have performed guest spots on his tracks, including 2pac and Mac Mall.